Aims: To investigate the neurotrophin-4 (NT-4) delivered locally in promoting skeletal muscle subtype recovery following sciatic nerve repair. Methods: Twelve adult male Sprague-Dawley rats were divided into NT-4 treated and control groups with six rats in each. The treated group received NT-4 mixed in a fibrin glue, while saline was incorporated for the controls. The left sciatic nerve was transected and immediately repaired and the fibrin glue injected around the nerve repair site. Muscle specimens, including tibialis anterior and gastrocemius were collected 60 days after nerve repair. The assessments included immunohistochemistry and immunoblotting. Results: There is statistically significant diference in type I muscle subtype distribution between NT-4 and control group. Conclusions: NT-4 can selectively improve type I muscle fibre subtype recovery.