Approximately 460,000 carpal tunnel releases are reported annually in the U.S., and the surgical cost is in excess of 2 billion dollars annually. Classically this syndrome was found to occur most often in (i) late middle-aged females; (ii) posttraumatic settings; (iii) inflammatory arthritis; and (iv) diabetes. Over the last decade there has been a dramatic change in the patient population with carpal tunnel syndrome (CTS). Based on national data the population includes young industrial workers of either sex whose work involves repetitive motion. The objectives of the current investigation are to determine the role of gender and age among the patients reporting to the University of Mississippi Medical Center with CTS over the past 14 years, and secondly to investigate the possible risk factors in the development of CTS. The patient population consisted of all patients reporting to the University of Mississippi Medical Center with CTS during the past 14 years. The evaluation was conducted according to the rules and regulations established by the University Institutional Review Board for Human Subject and Use. Descriptive data analysis was conducted by using SPSS statistical software. The preliminary data collected from this investigation demonstrates: (i) statistical difference in both gender and age in patients with CTS, (ii) the race was found to be a statistically significant factor (black > white), and (iii) no differences were found between cases with CTS alone and CTS related to complication such trauma, diabetes and pregnancy. The analysis of this study revealed that the socioeconomic status plays a major role in the etiology of CTS. In addition, this study along with other data provides more insights regarding specific geographical data for preventative interventions to minimize carpal tunnel occurrence, and can be used as a model for other geographical areas.